Study

Metastatic Breast Cancer Validation

Study ID Alternative Stable ID Type
EGAS00001001968 Cancer Genomics

Study Description

Validation of point mutations and small insertions and deletions in primary and associated metastatic breast cancer samples with matched normal tissues.

Study Datasets 1 dataset.

Click on a Dataset ID in the table below to learn more, and to find out who to contact about access to these data

Dataset ID Description Technology Samples
EGAD00001002698
Recurrent breast cancer is almost universally fatal. We characterize 170 patients locally relapsed or distant metastatic cancers using massively parallel sequencing. We identify that the relapse-seeding clone disseminates late from the primary tumor. TP53 and AKT1 appear to be enriched in ER-positive cancers predisposed to relapse. Mutation acquisition continues at relapse as the same mutation signatures continue to operate and new signatures, such as that caused by radiotherapy appear de novo. ... (Show More)
Illumina HiSeq 2000,Illumina HiSeq 2500,Illumina MiSeq 387

Who archives the data?

There are no publications available