Breast Heterogeneity Validation
|Study ID||Alternative Stable ID||Type|
Study Datasets 1 dataset.
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Recurrent breast cancer is almost universally fatal. We characterize 170 patients locally relapsed or distant metastatic cancers using massively parallel sequencing. We identify that the relapse-seeding clone disseminates late from the primary tumor. TP53 and AKT1 appear to be enriched in ER-positive cancers predisposed to relapse. Mutation acquisition continues at relapse as the same mutation signatures continue to operate and new signatures, such as that caused by radiotherapy appear de novo. ... (Show More)
|Illumina HiSeq 2000,Illumina HiSeq 2500,Illumina MiSeq||387|