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Longitudinal analysis of treatment induced genomic alterations in gliomas

Here, we report the longitudinal whole exome sequencing analysis of a patient with a primary GBM and two recurrences, demonstrating the heterogeneity caused by the therapy induced molecular changes and their implications for clinical decision-making. This analysis revealed the impact of temporal evolution for tumors under the pressure of treatment. We presented that while targeted treatments eliminated some sensitive clones, there were clones that were enriched leading to resistance. This study demonstrates the importance of longitudinal genomic profiling to adjust to the dynamic nature of therapy induced molecular changes to improve the outcomes of precision therapies.

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Dataset ID Description Technology Samples
EGAD00001003164 3
Publications Citations
Longitudinal analysis of treatment-induced genomic alterations in gliomas.
Genome Med 9: 2017 12