Sequencing of pancreatic cancer primary tumors and metastases

Study ID Alternative Stable ID Type
EGAS00001002186 Other

Study Description

The extent of heterogeneity of driver gene mutations present in naturally occurring metastases is largely unknown, i.e. treatment-naïve metastatic disease. To address this issue, 60x whole genome sequencing of 26 metastases from 4 patients was carried out. We found that the identical driver gene mutations were present in every metastatic lesion of each patient studied. Passenger gene mutations not known or predicted to have functional consequences accounted for all intratumoral heterogeneity. Even with respect to these passenger gene mutations, the genetic similarity among the founding cells of metastases was markedly higher than that expected for any two cells randomly taken from a normal tissue. The uniformity of driver gene mutations among metastases in the same patient has critical, encouraging implications for the success of future targeted therapies in advanced stage disease.

Study Datasets 1 dataset.

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Dataset ID Description Technology Samples
Sequencing of untreated pancreatic cancer metastases and primary tumor sections.
Illumina HiSeq 2000,Illumina HiSeq 2500 49

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