Organoid_Derivation_Project__WGS - EGA European Genome-phenome Archive

Click on a Dataset ID in the table below to learn more, and to find out who to contact about access to these data

Dataset ID	Description	Technology	Samples
EGAD00001005000	Sequencing of tissue samples and their derived organoids from oesophageal, pancreatic and colorectal cancer patients.	HiSeq X Ten	42
EGAD00001005955	Sequencing of tissue samples and their derived organoids from oesophageal, pancreatic and colorectal cancer patients.	HiSeq X Ten	7
EGAD00001011090	Sequencing of tissue samples and their derived organoids from oesophageal, pancreatic and colorectal cancer patients. . This dataset contains all the data available for this study on 2023-06-22.	HiSeq X Ten Illumina NovaSeq 6000	29
EGAD00001011093	Sequencing of tissue samples and their derived organoids from oesophageal, pancreatic and colorectal cancer patients. . This dataset contains all the data available for this study on 2023-06-22.	Illumina NovaSeq 6000	140
EGAD00001015424	Sequencing of tissue samples and their derived organoids. This dataset contains a subset of colorectal and colorectal liver metastasis samples.	HiSeq X Ten Illumina NovaSeq 6000	1
EGAD00001015468	Targeted gene sequencing data from cancer patient-derived organoids and their matched tumour tissue samples. Part of a study to include genomic and transcriptomic sequencing data, along with CRISPR screening data from cancer patient-derived organoids and matched tumour tissues. Some organoids were developed as part of the Human Cancer Models Initiative (HCMI) in collaboration with Cancer Research UK (CRUK). The study includes organoids derived from colorectal, oesophageal, ovarian, pancreatic, and stomach cancer samples.	HiSeq X Ten Illumina HiSeq 4000 Illumina NovaSeq 6000	1
EGAD00001015469	Whole genome sequencing data from cancer patient-derived organoids and their matched tumour tissue samples. Part of a study to include genomic and transcriptomic sequencing data, along with CRISPR screening data from cancer patient-derived organoids and matched tumour tissues. Some organoids were developed as part of the Human Cancer Models Initiative (HCMI) in collaboration with Cancer Research UK (CRUK). The study includes organoids derived from colorectal, oesophageal, ovarian, pancreatic, and stomach cancer samples.	HiSeq X Ten Illumina HiSeq 4000 Illumina NovaSeq 6000	1
EGAD00001015470	RNA sequencing data from cancer patient-derived organoids. Part of a study to include genomic and transcriptomic sequencing data, along with CRISPR screening data from cancer patient-derived organoids and matched tumour tissues. Some organoids were developed as part of the Human Cancer Models Initiative (HCMI) in collaboration with Cancer Research UK (CRUK). The study includes organoids derived from colorectal, oesophageal, ovarian, pancreatic, and stomach cancer samples.	Illumina HiSeq 4000 Illumina NovaSeq 6000	1

Publications	Citations
A tumour-derived organoid biobank maps cancer gene dependencies. Herranz-Ors C, Bhosle SG, Beck AE, Gilbert JGR, Picco G, Espejo Valle-Inclan J, Muyas F, Valentini S, Andres AE, Ansari R, Barthorpe S, Battarbee G, Beaver CM, Brocklesby S, Cantwell J, Collins CA, Davis J, Dimitrova HG, Doran J, Efendi E, Evans K, Fekry M, Fowler TA, Garcia-Casado M, Griffiths JAT, Hall C, Hamer R, Hardy C, Hewitson Z, Hitch E, Holland L, Jackson DA, Joshi N, Kavasakali A, Letchford L, Lightfoot HB, Lingala H, Mali I, May K, Mironenko T, Morris J, Pacini C, Price S, Robert-Tissot G, Rogers HA, Smith JV, Smith K, Souster E, Spence WJ, Thomas F, Vieira SF, Walker S, Alfonsin G, Bermingham H, Coles H, Ennis DP, Freeman A, Giannone G, Grehan N, Griffiths EA, Hall J, Lee SL, Leung EYL, Loreno C, Millington C, Mirnezami A, Nutzinger B, Orzechowska K, Pinna CMA, Redmond AM, Roberts K, Roy S, Sanders DA, Taniere P, Vias M, Wanigasooriya K, OCCAMS Consortium, Stratton MR, Staudt LM, McDermott U, Brenton JD, McNeish IA, Biankin A, Sansom OJ, Cortes-Ciriano I, Underwood TJ, Fitzgerald RC, Beggs AD, Francies HE, Garnett MJ. Nature 657: 2026 765-774	5

Publications

Citations

A tumour-derived organoid biobank maps cancer gene dependencies.
Herranz-Ors C, Bhosle SG, Beck AE, Gilbert JGR, Picco G, Espejo Valle-Inclan J, Muyas F, Valentini S, Andres AE, Ansari R, Barthorpe S, Battarbee G, Beaver CM, Brocklesby S, Cantwell J, Collins CA, Davis J, Dimitrova HG, Doran J, Efendi E, Evans K, Fekry M, Fowler TA, Garcia-Casado M, Griffiths JAT, Hall C, Hamer R, Hardy C, Hewitson Z, Hitch E, Holland L, Jackson DA, Joshi N, Kavasakali A, Letchford L, Lightfoot HB, Lingala H, Mali I, May K, Mironenko T, Morris J, Pacini C, Price S, Robert-Tissot G, Rogers HA, Smith JV, Smith K, Souster E, Spence WJ, Thomas F, Vieira SF, Walker S, Alfonsin G, Bermingham H, Coles H, Ennis DP, Freeman A, Giannone G, Grehan N, Griffiths EA, Hall J, Lee SL, Leung EYL, Loreno C, Millington C, Mirnezami A, Nutzinger B, Orzechowska K, Pinna CMA, Redmond AM, Roberts K, Roy S, Sanders DA, Taniere P, Vias M, Wanigasooriya K, OCCAMS Consortium, Stratton MR, Staudt LM, McDermott U, Brenton JD, McNeish IA, Biankin A, Sansom OJ, Cortes-Ciriano I, Underwood TJ, Fitzgerald RC, Beggs AD, Francies HE, Garnett MJ. Nature 657: 2026 765-774