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Regions of common inter-individual DNA methylation differences in human monocytes.

Based on whole genome bisulfite sequencing of five human monocytes from unrelated individuals, we have identified regions of common inter-individual DNA methylation differences, where methylation is inversely correlated with active histone marks, but not with the expression of the associated genes. Genome-wide association studies in 1128 individuals show that allelic DNA methylation is caused by genetic variation in cis. At some loci, DNA methylation appears to be affected also by genetic variation in trans.

Click on a Dataset ID in the table below to learn more, and to find out who to contact about access to these data

Dataset ID Description Technology Samples
EGAD00001003259 Illumina HiSeq 2000 4
EGAD00010001294 Illumina 450k 1128
Publications Citations
Regions of common inter-individual DNA methylation differences in human monocytes: genetic basis and potential function.
Epigenetics Chromatin 10: 2017 37
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