WGS of AML during PARPi therapy

Study ID Alternative Stable ID Type
EGAS00001002274 Cancer Genomics

Study Description

We will require WGS on Illumina X10 machines of three samples, along with storage and computational power to perform the relevant analysis.

Study Datasets 1 dataset.

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Dataset ID Description Technology Samples
Analysis of mutational signatures is becoming routine in cancer genomics, with implications for pathogenesis, classification, prognosis, and even treatment decisions. However, the field lacks a consensus on analysis and result interpretation. Using whole-genome sequencing of multiple myeloma (MM), chronic lymphocytic leukemia (CLL) and acute myeloid leukemia, we compare the performance of public signature analysis tools. We describe caveats and pitfalls of de novo signature extraction and ... (Show More)
HiSeq X Ten 5

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