Study

Whole genome, whole exome, and targeted sequencing of high-grade meningioma tumor samples.

Study ID Alternative Stable ID Type
EGAS00001002294 Other

Study Description

High-grade meningiomas frequently recur and are associated with high rates of morbidity and mortality. To determine the factors that promote the development and evolution of these tumors, we analyzed the genomes of 274 high-grade meningiomas and compared this information with data from 456 low-grade meningiomas. High-grade meningiomas had a higher mutation burden than low-grade meningiomas but did not harbor any statistically significant mutated genes aside from NF2. High-grade meningiomas also possessed significantly elevated rates of chromosomal gains and losses, especially among tumors with monosomy 22. Meningiomas previously treated with adjuvant radiation had significantly more copy number alterations than radiation-induced or radiation-naïve meningiomas. Across serial recurrences, genomic disruption preceded the emergence of nearly all mutations, remained largely uniform across time, and when present in low-grade meningiomas, correlated with subsequent progression to a higher grade. In contrast to the largely stable copy number alterations, mutations were strikingly ... (Show More)

Study Datasets 1 dataset.

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Dataset ID Description Technology Samples
EGAD00001003220
Whole genome, whole exome, and custom panel sequencing of high-grade meningioma cohort
188

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