Study

The Ovarian Cancer Association Consortium OncoArray genome-wide association study

Study ID Alternative Stable ID Type
EGAS00001002305 Other

Study Description

A custom Illumina genotyping array, the OncoArray. The array includes a genome-wide backbone, comprising 230,000 SNPs tagging most common genetic variants, together with dense mapping of known susceptibility regions, rare variants from sequencing experiments, pharmacogenetic markers, and cancer-related traits. A total of 494,763 SNPs passed quality control steps with a sample success rate of 97% of the samples. Participating sites performed ancestry analysis using a common set of markers and a scoring algorithm based on principal components analysis as described in PMID:27697780.The array was used to genotype ovarian cancer cases and controls from multiple studies participating in the Ovarian Cancer Association Consortium, of which 54,747 passes QC.An initial principal components analysis was carried out using a method described in PMID:27697780 to assign subject to intercontinental ancestry groups: “European”, “African”, “Asian” and "Other". Within ancestry principal components analysis was carried using a set of ~33k unlinked markers. Subsequent analyses were ... (Show More)

Study Datasets 1 dataset.

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Dataset ID Description Technology Samples
EGAD00010001192
Germline genotype data on 56,479 ovarian cancer cases and controls
Illumina OncoArray 56479

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