Study

Whole-Genome Sequencing of a Healthy Aging Cohort.

Study ID Alternative Stable ID Type
EGAS00001002306 Other

Study Description

Studies of long-lived individuals have revealed few genetic mechanisms for protection against age-associated disease. Therefore, we pursued genome sequencing of a related phenotype-healthy aging-to understand the genetics of disease-free aging without medical intervention. In contrast with studies of exceptional longevity, usually focused on centenarians, healthy aging is not associated with known longevity variants, but is associated with reduced genetic susceptibility to Alzheimer and coronary artery disease. Additionally, healthy aging is not associated with a decreased rate of rare pathogenic variants, potentially indicating the presence of disease-resistance factors. In keeping with this possibility, we identify suggestive common and rare variant genetic associations implying that protection against cognitive decline is a genetic component of healthy aging. These findings, based on a relatively small cohort, require independent replication. Overall, our results suggest healthy aging is an overlapping but distinct phenotype from exceptional longevity that may be enriched with ... (Show More)

Study Datasets 1 dataset.

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Dataset ID Description Technology Samples
EGAD00001003941
Whole-Genome Sequencing of a Healthy Aging Cohort.
Complete Genomics 511

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