Poly(A) RNA sequencing of hepatocellular carcinoma tumors and their matched noncancerous liver tissues

Study ID Alternative Stable ID Type
EGAS00001002337 Other

Study Description

Background & Aims: The differentiation of distinct multifocal hepatocellular carcinoma (HCC): multicentric disease vs. intrahepatic metastases, in which the management and prognosis varies substantively, remains problematic. We aim to stratify multifocal HCC and identify novel diagnostic and prognostic biomarkers by performing whole genome and transcriptome sequencing, as part of a multi-omics strategy Methods: A complete collection of tumour and somatic specimens (intrahepatic HCC lesions, matched non-cancerous liver tissue and blood) were obtained from representative patientswith multifocal HCC exhibiting two distinct postsurgical courses. Whole-genome and transcriptome sequencing with genotyping were performed for each tissue specimen to con-trast genomic alterations, including hepatitis B virus integrations, somatic mutations, copy number variations, and structural variations. We then constructed a phylogenetic tree to visualise individual tumour evolution and performed functional enrichment analyses on select differentially expressed genes to elucidate biological processes ... (Show More)

Study Datasets 1 dataset.

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Dataset ID Description Technology Samples
Poly A transcriptome sequence of mutifocal hepatocelular carcinoma
Illumina HiSeq 2000 7

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