Study ID Alternative Stable ID Type
EGAS00001002366 Cancer Genomics

Study Description

Study of the genetic and epigenetic clonal evolution of blood cancers.

Study Datasets 1 dataset.

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Dataset ID Description Technology Samples
The discovery of the BRAF V600E mutation in almost all cases of hairy-cell leukemia has led to the widespread adoption of the BRAF inhibitor vemurafenib for treatment of chemotherapy-resistant cases. Impressive responses are reported; however, acquired resistance is common. Whilst diverse mechanisms of vemurafenib resistance have been elucidated in melanoma, the basis of resistance in HCL is unclear. Here we apply whole genome and deep targeted sequencing to investigate resistance mechanisms ... (Show More)
HiSeq X Ten 3

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