Evolution of the cancer epigenome in myeloproliferative neoplasms 2
|Study ID||Alternative Stable ID||Type|
Study Datasets 1 dataset.
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Mutations in cancer-associated genes drive tumour outgrowth. However, the timing of driver mutations and dynamics of clonal expansion that lead to human cancers are largely unknown. We used 580,133 somatic mutations from whole-genome sequencing of 1013 clonal haematopoietic colonies to reconstruct the phylogeny of haematopoiesis, from embryogenesis to clinical disease, in 12 patients with myeloproliferative neoplasms which are blood cancers more common in older age. JAK2V617F, the pathognomonic ... (Show More)
|HiSeq X Ten,Illumina HiSeq 2000||1029|