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Subclonal evolution of four ER+ breast cancers determined by WGS and scRNA-Seq

We analyzed the subclonal evolution of four ER+ breast cancers over 2-15 years using whole-genome sequencing (WGS) and single-cell RNA-Seq (scRNA-Seq). For each patient we analyzed 2-6 cancer samples, generally metastatic pleural effusions or ascites, by WGS, along with germline DNA. Two of the samples per patient were selected for single-cell RNA-Seq.

Click on a Dataset ID in the table below to learn more, and to find out who to contact about access to these data

Dataset ID Description Technology Samples
EGAD00001003303 16
Publications Citations
Combating subclonal evolution of resistant cancer phenotypes.
Nat Commun 8: 2017 1231
Mobile element insertions and associated structural variants in longitudinal breast cancer samples.
Sci Rep 11: 2021 13020
Phylogenetic inference from single-cell RNA-seq data.
Sci Rep 13: 2023 12854
A Bayesian framework to study tumor subclone-specific expression by combining bulk DNA and single-cell RNA sequencing data.
Genome Res 34: 2024 94-105