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SNP array data for the Milieu Intérieur cohort

The Milieu Intérieur Consortium aims at identifying the environmental and genetic factors driving variation in innate and adaptive immune systems among healthy individuals. In the last four years, we combined standardized flow cytometric analysis of blood leukocytes, transcriptional profiles of whole blood after immune stimulation and genome-wide DNA genotyping in 1,000 healthy, unrelated donors of western European ancestry, to show that age, sex, as well as persistent infections and smoking, are the most important drivers of inter-individual differences in blood cell composition and transcriptional response to pathogens. The EGAS00001002460 study includes genotype data for 5,699,237 genotyped and imputed SNPs in the 816 healthy donors of the Milieu Intérieur cohort. Note that 184 of the 1,000 initial donors did not agree to share their data online.

Click on a Dataset ID in the table below to learn more, and to find out who to contact about access to these data

Dataset ID Description Technology Samples
EGAD00010001489 816
Publications Citations
Distinctive roles of age, sex, and genetics in shaping transcriptional variation of human immune responses to microbial challenges.
Proc Natl Acad Sci U S A 115: 2018 E488-E497
106
Human genetic variants and age are the strongest predictors of humoral immune responses to common pathogens and vaccines.
Genome Med 10: 2018 59
77
A comprehensive assessment of demographic, environmental, and host genetic associations with gut microbiome diversity in healthy individuals.
Microbiome 7: 2019 130
67
Quantitative genetic analysis deciphers the impact of cis and trans regulation on cell-to-cell variability in protein expression levels.
PLoS Genet 16: 2020 e1008686
8
Vaccine-induced ICOS<sup>+</sup>CD38<sup>+</sup> circulating Tfh are sensitive biosensors of age-related changes in inflammatory pathways.
Cell Rep Med 2: 2021 100262
29
Integrative genetic and immune cell analysis of plasma proteins in healthy donors identifies novel associations involving primary immune deficiency genes.
Genome Med 14: 2022 28
9
Early IFNβ secretion determines variable downstream IL-12p70 responses upon TLR4 activation.
Cell Rep 39: 2022 110989
2
The immune factors driving DNA methylation variation in human blood.
Nat Commun 13: 2022 5895
23
Unveiling <i>Candida albicans</i> intestinal carriage in healthy volunteers: the role of micro- and mycobiota, diet, host genetics and immune response.
Gut Microbes 15: 2023 2287618
1
Smoking changes adaptive immunity with persistent effects.
Nature 626: 2024 827-835
4