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Profiling_molecular_heterogeneity_in_human_primary_microglia

In the brain the cells that control inflammation are called a type of white blood cell called microglia. Microglia are located throughout the brain and spinal cord and account for 10–15% of all cells found within the brain. As the resident white blood cells, they are the main active immune defence in the central nervous system (CNS). Microglia are part of an important class of cells known as macrophages that have two main states: M1 and M2. M1 cells are pro- inflammatory, leading to more inflammation, while M2 are anti-inflammatory, and drive wound healing. In this study, we will collect primary microglia from surgical biospies of 100 individuals. This data is part of a pre-publication release. For information on the proper use of pre-publication data shared by the Wellcome Trust Sanger Institute (including details of any publication moratoria), please see http://www.sanger.ac.uk/datasharing/

Click on a Dataset ID in the table below to learn more, and to find out who to contact about access to these data

Dataset ID Description Technology Samples
EGAD00001005736 8787
Publications Citations
Genome-wide meta-analysis, fine-mapping and integrative prioritization implicate new Alzheimer's disease risk genes.
Nat Genet 53: 2021 392-402
120
A map of transcriptional heterogeneity and regulatory variation in human microglia.
Nat Genet 53: 2021 861-868
50
A genome-wide association study with 1,126,563 individuals identifies new risk loci for Alzheimer's disease.
Nat Genet 53: 2021 1276-1282
192
Genetics of the human microglia regulome refines Alzheimer's disease risk loci.
Nat Genet 54: 2022 1145-1154
12