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Fibroblast heterogeneity and immunosuppressive environment in Human breast cancer

Carcinoma-associated fibroblasts (CAF) are key players in the tumor microenvironment. Here, by combining 6 well-known stromal markers, we identify four CAF subsets (CAF-S1 to CAF-S4) in human breast cancer (BC) that exhibit distinct activation patterns and accumulate differently in BC subtypes.

Click on a Dataset ID in the table below to learn more, and to find out who to contact about access to these data

Dataset ID Description Technology Samples
EGAD00001003808 Illumina HiSeq 2500 47
Publications Citations
A subset of activated fibroblasts is associated with distant relapse in early luminal breast cancer.
Breast Cancer Res 22: 2020 76
Dissection of intercellular communication using the transcriptome-based framework ICELLNET.
Nat Commun 12: 2021 1089