Study

Genome-wide genetic and epigenetic dataset of pancreatic acinar cell carcinomas

Study ID Alternative Stable ID Type
EGAS00001002533 Other

Study Description

Pancreatic acinar cell carcinoma (ACC) is an aggressive exocrine tumor with largely unknown biology. To identify potential targets for personalized treatment, integrative genome- and epigenome-wide analyses were performed. The results show frequently aberrant DNA methylation, abundant chromosomal amplifications and deletions, and mutational signatures suggesting defective DNA repair. In contrast to pancreatic ductal adenocarcinoma, no recurrent point mutations are known. The tumor suppressors ID3, ARID1A, APC, and CDKN2A are frequently impaired also on the protein level and thus potentially affect ACC tumorigenesis. Consequently, this work identifies potential novel therapeutic targets in ACC for drugs recently approved for precision cancer therapy.

Study Datasets 1 dataset.

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Dataset ID Description Technology Samples
EGAD00010001298
primary human ACC and normal samples using 450K
Illumina_450K 110

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