Study
Y chromosome mis segregation in the DLD 1 cell line
Study ID | Alternative Stable ID | Type |
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EGAS00001002551 | Cancer Genomics |
Study Description
Study of the well-established DLD-1 colorectal cancer cell line, engineered with an inactivatable Y centromere that leads to mis-segregation. The goal is to gain insights into the mechanism of chromothripsis due to chromosome mis-segration.
Study Datasets 1 dataset.
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Dataset ID | Description | Technology | Samples |
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EGAD00001004163 |
Cancer genomes are frequently characterized by numerical and structural karyotypic abnormalities. Here we combined an inducible centromere-specific inactivation approach with selection for a conditionally essential gene, a strategy we term ‘CEN-SELECT’, and show that single-chromosome missegregation during cell division can directly drive a broad spectrum of structural rearrangement types. Cytogenetic profiling revealed that missegregated chromosomes are 120-fold more susceptible to ... (Show More)
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HiSeq X Ten,Illumina HiSeq 2000 | 22 |
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