Y chromosome mis segregation in the DLD 1 cell line

Study ID Alternative Stable ID Type
EGAS00001002551 Cancer Genomics

Study Description

Study of the well-established DLD-1 colorectal cancer cell line, engineered with an inactivatable Y centromere that leads to mis-segregation. The goal is to gain insights into the mechanism of chromothripsis due to chromosome mis-segration.

Study Datasets 1 dataset.

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Dataset ID Description Technology Samples
Cancer genomes are frequently characterized by numerical and structural karyotypic abnormalities. Here we combined an inducible centromere-specific inactivation approach with selection for a conditionally essential gene, a strategy we term ‘CEN-SELECT’, and show that single-chromosome missegregation during cell division can directly drive a broad spectrum of structural rearrangement types. Cytogenetic profiling revealed that missegregated chromosomes are 120-fold more susceptible to ... (Show More)
HiSeq X Ten,Illumina HiSeq 2000 22

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