The genetics of thinness compared to obesity

Study ID Alternative Stable ID Type
EGAS00001002624 Population Genomics

Study Description

The variation in weight within a shared environment is largely attributable to genetic factors. Whilst many genes/loci confer susceptibility to obesity, little is known about the genetic architecture of thinness. In this study we performed a genome-wide association study of 1,622 persistently thin healthy individuals (STILTS), 1,985 severe childhood onset obesity cases (SCOOP) and 10,433 population based individuals (UKHLS) used as a common set of controls. All participants were genotyped on the Illumina Core Exome array, including 551,839 markers and imputed to the combined UK10K and 1000G (phase3) reference panel. We contrast the genetic architecture of thinness with that of severe early onset obesity and explore whether the genetic loci influencing thinness are the same as those influencing obesity pr whether there are important genetic differences between them. This data is part of a pre-publication release. For information on the proper use of pre-publication data shared by the Wellcome Trust Sanger Institute (including details of any publication moratoria), please see ... (Show More)

Study Datasets 3 datasets.

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Dataset ID Description Technology Samples
Human Core Exome Genotyping for 1471 samples from the STudy Into Lean and Thin Subjects (STILTS) cohort
Illumina humancoreexome-12v1-1_a 1471
Human Core Exome Genotyping for 1456 severe early onset obesity cases (SCOOP)
Illumina humancoreexome-12v1-1_a 1456
Genetics of thinness compared to obesity - summary statistics
Illumina humancoreexome-12v1-1_a 2927

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