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Genetic determinants of glycated hemoglobin levels in the Greenlandic Inuit population

We recently showed that a common genetic variant leads to a remarkably increased risk of type 2 diabetes (T2D) in the small and historically isolated Greenlandic population. Motivated by this, we aimed at investigating the genetic determinants for glycated hemoglobin (HbA1C). We found no novel associations but saw that for 10 out of 15 known HbA1C loci that the effects in Greenlandic Inuit were similar to previously reported. One locus, ANK1, showed a significant ancestral population specific effect. Our results shed light on the genetics effects across ethnicites.

Click on a Dataset ID in the table below to learn more, and to find out who to contact about access to these data

Dataset ID Description Technology Samples
EGAD00010001427 Illumina 1336
EGAD00010001428 Illumina 2791
Publications Citations
Genetic determinants of glycated hemoglobin levels in the Greenlandic Inuit population.
Eur J Hum Genet 26: 2018 868-875
Identification of novel high-impact recessively inherited type 2 diabetes risk variants in the Greenlandic population.
Diabetologia 61: 2018 2005-2015
The derived allele of a novel intergenic variant at chromosome 11 associates with lower body mass index and a favorable metabolic phenotype in Greenlanders.
PLoS Genet 16: 2020 e1008544
Estimating narrow-sense heritability using family data from admixed populations.
Heredity (Edinb) 124: 2020 751-762
Genetic study of the Arctic CPT1A variant suggests that its effect on fatty acid levels is modulated by traditional Inuit diet.
Eur J Hum Genet 28: 2020 1592-1601
Abdominal visceral and subcutaneous adipose tissue and associations with cardiometabolic risk in Inuit, Africans and Europeans: a cross-sectional study.
BMJ Open 10: 2020 e038071
The genetic history of Greenlandic-European contact.
Curr Biol 31: 2021 2214-2219.e4
Physical activity attenuates postprandial hyperglycaemia in homozygous TBC1D4 loss-of-function mutation carriers.
Diabetologia 64: 2021 1795-1804
An <i>LDLR</i> missense variant poses high risk of familial hypercholesterolemia in 30% of Greenlanders and offers potential of early cardiovascular disease intervention.
HGG Adv 3: 2022 100118
GWAS of lipids in Greenlanders finds association signals shared with Europeans and reveals an independent PCSK9 association signal.
Eur J Hum Genet 32: 2024 215-223