Genetic determinants of glycated hemoglobin levels in the Greenlandic Inuit population

We recently showed that a common genetic variant leads to a remarkably increased risk of type 2 diabetes (T2D) in the small and historically isolated Greenlandic population. Motivated by this, we aimed at investigating the genetic determinants for glycated hemoglobin (HbA1C). We found no novel associations but saw that for 10 out of 15 known HbA1C loci that the effects in Greenlandic Inuit were similar to previously reported. One locus, ANK1, showed a significant ancestral population specific effect. Our results shed light on the genetics effects across ethnicites.

Type: Other
Archiver: European Genome-Phenome Archive (EGA)

2 Datasets 10 Publications

Click on a Dataset ID in the table below to learn more, and to find out who to contact about access to these data

Dataset ID	Description	Technology	Samples
EGAD00010001427	Cardio-Metabochip genotypes for B99 cohort	Illumina	1336
EGAD00010001428	Cardio-Metabochip genotypes for IHIT cohort	Illumina	2791

Publications	Citations
Genetic determinants of glycated hemoglobin levels in the Greenlandic Inuit population. Appel EVR, Moltke I, Jørgensen ME, Bjerregaard P, Linneberg A, Pedersen O, Albrechtsen A, Hansen T, Grarup N. Eur J Hum Genet 26: 2018 868-875	2
Identification of novel high-impact recessively inherited type 2 diabetes risk variants in the Greenlandic population. Grarup N, Moltke I, Andersen MK, Bjerregaard P, Larsen CVL, Dahl-Petersen IK, Jørsboe E, Tiwari HK, Hopkins SE, Wiener HW, Boyer BB, Linneberg A, Pedersen O, Jørgensen ME, Albrechtsen A, Hansen T. Diabetologia 61: 2018 2005-2015	9
The derived allele of a novel intergenic variant at chromosome 11 associates with lower body mass index and a favorable metabolic phenotype in Greenlanders. Andersen MK, Jørsboe E, Skotte L, Hanghøj K, Sandholt CH, Moltke I, Grarup N, Kern T, Mahendran Y, Søborg B, Bjerregaard P, Larsen CVL, Dahl-Petersen IK, Tiwari HK, Feenstra B, Koch A, Wiener HW, Hopkins SE, Pedersen O, Melbye M, Boyer BB, Jørgensen ME, Albrechtsen A, Hansen T. PLoS Genet 16: 2020 e1008544	3
Estimating narrow-sense heritability using family data from admixed populations. Athanasiadis G, Speed D, Andersen MK, Appel EVR, Grarup N, Brandslund I, Jørgensen ME, Larsen CVL, Bjerregaard P, Hansen T, Albrechtsen A. Heredity (Edinb) 124: 2020 751-762	5
Genetic study of the Arctic CPT1A variant suggests that its effect on fatty acid levels is modulated by traditional Inuit diet. Senftleber N, Jørgensen ME, Jørsboe E, Imamura F, Forouhi NG, Larsen CL, Bjerregaard P, Hansen T, Albrechtsen A. Eur J Hum Genet 28: 2020 1592-1601	4
Abdominal visceral and subcutaneous adipose tissue and associations with cardiometabolic risk in Inuit, Africans and Europeans: a cross-sectional study. Rønn PF, Andersen GS, Lauritzen T, Christensen DL, Aadahl M, Carstensen B, Grarup N, Jørgensen ME. BMJ Open 10: 2020 e038071	10
The genetic history of Greenlandic-European contact. Waples RK, Hauptmann AL, Seiding I, Jørsboe E, Jørgensen ME, Grarup N, Andersen MK, Larsen CVL, Bjerregaard P, Hellenthal G, Hansen T, Albrechtsen A, Moltke I. Curr Biol 31: 2021 2214-2219.e4	6
Physical activity attenuates postprandial hyperglycaemia in homozygous TBC1D4 loss-of-function mutation carriers. Schnurr TM, Jørsboe E, Chadt A, Dahl-Petersen IK, Kristensen JM, Wojtaszewski JFP, Springer C, Bjerregaard P, Brage S, Pedersen O, Moltke I, Grarup N, Al-Hasani H, Albrechtsen A, Jørgensen ME, Hansen T. Diabetologia 64: 2021 1795-1804	4
An <i>LDLR</i> missense variant poses high risk of familial hypercholesterolemia in 30% of Greenlanders and offers potential of early cardiovascular disease intervention. Jørsboe E, Andersen MK, Skotte L, Stæger FF, Færgeman NJ, Hanghøj K, Santander CG, Senftleber NK, Diaz LJ, Overvad M, Waples RK, Geller F, Bjerregaard P, Melbye M, Larsen CVL, Feenstra B, Anders Koch, Jørgensen ME, Grarup N, Moltke I, Albrechtsen A, Hansen T. HGG Adv 3: 2022 100118	5
GWAS of lipids in Greenlanders finds association signals shared with Europeans and reveals an independent PCSK9 association signal. Senftleber NK, Andersen MK, Jørsboe E, Stæger FF, Nøhr AK, Garcia-Erill G, Meisner J, Santander CG, Balboa RF, Gilly A, Bjerregaard P, Larsen CVL, Grarup N, Jørgensen ME, Zeggini E, Moltke I, Hansen T, Albrechtsen A. Eur J Hum Genet 32: 2024 215-223	1