Study
Genome-wide search for higher order epistasis as modifiers of treatment effects on bone mineral density in childhood cancer survivors
| Study ID | Alternative Stable ID | Type |
|---|---|---|
| EGAS00001002645 | Other |
Study Description
Survivors of pediatric acute lymphoblastic leukemia (ALL) exposed to curative treatments that adversely affect BMD (age- and sex-adjusted BMD Z-scores, measured via QCT). Specifically, after SNP QC and annotation, we considered 75523 autosomal SNPs mapped to putative promoter or enhancer regions to restrict our search to 3-way SNP interactions that potentially reflect gene regulation events that influence BMD. We replicated 3-SNP interactions as modifiers of treatment effects in a cohort of adult survivors of non-ALL pediatric cancers (N=1428).
Study Datasets 2 datasets.
Click on a Dataset ID in the table below to learn more, and to find out who to contact about access to these data
| Dataset ID | Description | Technology | Samples |
|---|---|---|---|
| EGAD00010001395 |
A replication cohort consisting of 1428 adult survivors of any non-ALL pediatric cancer
|
Genome-Wide Human SNP Array 6.0 - Thermo Fisher Scientific | 1428 |
| EGAD00010001396 |
A discovery cohort of 856 adult survivors of pediatric ALL
|
Genome-Wide Human SNP Array 6.0 - Thermo Fisher Scientific | 856 |
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