Study

Genome-wide search for higher order epistasis as modifiers of treatment effects on bone mineral density in childhood cancer survivors

Study ID Alternative Stable ID Type
EGAS00001002645 Other

Study Description

Survivors of pediatric acute lymphoblastic leukemia (ALL) exposed to curative treatments that adversely affect BMD (age- and sex-adjusted BMD Z-scores, measured via QCT). Specifically, after SNP QC and annotation, we considered 75523 autosomal SNPs mapped to putative promoter or enhancer regions to restrict our search to 3-way SNP interactions that potentially reflect gene regulation events that influence BMD. We replicated 3-SNP interactions as modifiers of treatment effects in a cohort of adult survivors of non-ALL pediatric cancers (N=1428).

Study Datasets 2 datasets.

Click on a Dataset ID in the table below to learn more, and to find out who to contact about access to these data

Dataset ID Description Technology Samples
EGAD00010001395
A replication cohort consisting of 1428 adult survivors of any non-ALL pediatric cancer
Genome-Wide Human SNP Array 6.0 - Thermo Fisher Scientific 1428
EGAD00010001396
A discovery cohort of 856 adult survivors of pediatric ALL
Genome-Wide Human SNP Array 6.0 - Thermo Fisher Scientific 856

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