Genome-wide search for higher order epistasis as modifiers of treatment effects on bone mineral density in childhood cancer survivors

Survivors of pediatric acute lymphoblastic leukemia (ALL) exposed to curative treatments that adversely affect BMD (age- and sex-adjusted BMD Z-scores, measured via QCT). Specifically, after SNP QC and annotation, we considered 75523 autosomal SNPs mapped to putative promoter or enhancer regions to restrict our search to 3-way SNP interactions that potentially reflect gene regulation events that influence BMD. We replicated 3-SNP interactions as modifiers of treatment effects in a cohort of adult survivors of non-ALL pediatric cancers (N=1428).

Type: Other
Archiver: European Genome-Phenome Archive (EGA)

2 Datasets 1 Publication

Click on a Dataset ID in the table below to learn more, and to find out who to contact about access to these data

Dataset ID	Description	Technology	Samples
EGAD00010001395	A replication cohort consisting of 1428 adult survivors of any non-ALL pediatric cancer	Genome-Wide Human SNP Array 6.0 - Thermo Fisher Scientific	1428
EGAD00010001396	A discovery cohort of 856 adult survivors of pediatric ALL	Genome-Wide Human SNP Array 6.0 - Thermo Fisher Scientific	856

Publications	Citations
Genome-wide search for higher order epistasis as modifiers of treatment effects on bone mineral density in childhood cancer survivors. Im C, Ness KK, Kaste SC, Chemaitilly W, Moon W, Sapkota Y, Brooke RJ, Hudson MM, Robison LL, Yasui Y, Wilson CL. Eur J Hum Genet 26: 2018 275-286	4