Employing single cell sequencing for detection of mutational signatures reflecting on going mutagenesis
|Study ID||Alternative Stable ID||Type|
Study Datasets 1 dataset.
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Multiple signatures of somatic mutations have been identified in human cancer genomes. To investigate whether mutational signatures continue to be generated, and if so their temporal patterns of activity, subsets of cell lines were cultured in vitro for extended periods and subjected to single cell cloning and whole genome or exome sequencing or directly to single cell whole genome sequencing. As expected, signatures of past exogenous exposures, such as tobacco smoke and ultraviolet light, were ... (Show More)
|HiSeq X Ten||192|