Employing single cell sequencing for detection of mutational signatures reflecting on going mutagenesis

Study ID Alternative Stable ID Type
EGAS00001002679 Cancer Genomics

Study Description

12 single cells will be sequenced from a previously single-cell derived clone of a JSC-1 cell line. Additional 12 single cells are likely to be sequenced from a previously single-cell derived clone of a SW756 line. Both belong to CGP’s panel of approximately 1000 human cancer cell lines.

Study Datasets 1 dataset.

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Dataset ID Description Technology Samples
Multiple signatures of somatic mutations have been identified in human cancer genomes. To investigate whether mutational signatures continue to be generated, and if so their temporal patterns of activity, subsets of cell lines were cultured in vitro for extended periods and subjected to single cell cloning and whole genome or exome sequencing or directly to single cell whole genome sequencing. As expected, signatures of past exogenous exposures, such as tobacco smoke and ultraviolet light, were ... (Show More)
HiSeq X Ten 192

Who archives the data?

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