Comprehensive genomic profiling of matched glioblastoma tumours, cell-lines, and xenografts reveals genomic stability and adaptation to disparate growth environments

The mandate of this project was to use drug screening to deliver new drugs for glioblastoma (GBM) to clinical trials, and perform genomic assessment of GBM to discover new therapeutic targets and predictors of response. The sequencing data in this set was derived from GBM patient tumor samples, matched brain tumor initiating cells lines (BTICs), and tumor tissue derived from orthotopic implants.

Type: Other
Archiver: European Genome-Phenome Archive (EGA)

61 Datasets 4 Publications

Click on a Dataset ID in the table below to learn more, and to find out who to contact about access to these data

Dataset ID	Description	Technology	Samples
EGAD00001004221	WGS and RNA-Seq data from a GBM patient PT-AB0029	Illumina HiSeq 2000	-
EGAD00001004222	WGS and RNA-Seq data from a GBM patient PT-AB6372	Illumina HiSeq 2000 Illumina HiSeq 2500	2
EGAD00001004223	WGS and RNA-Seq data from a GBM patient PT-AH1410	Illumina HiSeq 2000	-
EGAD00001004224	WGS and RNA-Seq data from a GBM patient PT-AK7565	Illumina HiSeq 2500	-
EGAD00001004225	WGS and RNA-Seq data from a GBM patient PT-AL4257	Illumina HiSeq 2000 Illumina HiSeq 2500	2
EGAD00001004226	Genome sequence data from a GBM patient PT-AR3050	Illumina HiSeq 2500	-
EGAD00001004227	WGS and RNA-Seq data from a GBM patient PT-AR5365	Illumina HiSeq 2000 Illumina HiSeq 2500	1
EGAD00001004228	WGS and RNA-Seq data from a GBM patient PT-BK0248	Illumina HiSeq 2500	-
EGAD00001004229	WGS and RNA-Seq data from a GBM patient PT-BM772	Illumina HiSeq 2000	1
EGAD00001004230	WGS and RNA-Seq data from a GBM patient PT-CA2271	Illumina HiSeq 2000 Illumina HiSeq 2500	-
EGAD00001004231	WGS and RNA-Seq data from a GBM patient PT-CM1209	Illumina HiSeq 2000 Illumina HiSeq 2500	2
EGAD00001004232	WGS and RNA-Seq data from a GBM patient PT-DF5919	Illumina HiSeq 2000 Illumina HiSeq 2500	2
EGAD00001004233	WGS and RNA-Seq data from a GBM patient PT-DS9789	Illumina HiSeq 2000 Illumina HiSeq 2500	1
EGAD00001004234	WGS and RNA-Seq data from a GBM patient PT-EV3071	Illumina HiSeq 2000 Illumina HiSeq 2500	-
EGAD00001004235	WGS and RNA-Seq data from a GBM patient PT-FB6711	Illumina HiSeq 2000	1
EGAD00001004236	Genome sequence data from a GBM patient PT-FR7453		-
EGAD00001004237	WGS and RNA-Seq data from a GBM patient PT-GB9186	Illumina HiSeq 2000	-
EGAD00001004238	WGS and RNA-Seq data from a GBM patient PT-GB9483	Illumina HiSeq 2500	-
EGAD00001004239	WGS and RNA-Seq data from a GBM patient PT-GC1519	Illumina HiSeq 2500	1
EGAD00001004240	WGS and RNA-Seq data from a GBM patient PT-GJ3716	Illumina HiSeq 2500	2
EGAD00001004241	WGS and RNA-Seq data from a GBM patient PT-GR2309	Illumina HiSeq 2500	-
EGAD00001004242	WGS and RNA-Seq data from a GBM patient PT-HN6692	Illumina HiSeq 2500	-
EGAD00001004243	WGS and RNA-Seq data from a GBM patient PT-HO0394	Illumina HiSeq 2000 Illumina HiSeq 2500	-
EGAD00001004244	WGS data from a GBM patient PT-HS9105		-
EGAD00001004245	WGS and RNA-Seq data from a GBM patient PT-JB1730	Illumina HiSeq 2000	-
EGAD00001004246	WGS and RNA-Seq data from a GBM patient PT-JE6375	Illumina HiSeq 2000 Illumina HiSeq 2500	-
EGAD00001004247	WGS and RNA-Seq data from a GBM patient PT-JP2405	Illumina HiSeq 2500	-
EGAD00001004248	WGS and RNA-Seq data from a GBM patient PT-JW6420	Illumina HiSeq 2000 Illumina HiSeq 2500	1
EGAD00001004249	WGS and RNA-Seq data from a GBM patient PT-KM5291	Illumina HiSeq 2000 Illumina HiSeq 2500	1
EGAD00001004250	WGS and RNA-Seq data from a GBM patient PT-LC3356	Illumina HiSeq 2000 Illumina HiSeq 2500	1
EGAD00001004251	WGS and RNA-Seq data from a GBM patient PT-LR9369	Illumina HiSeq 2000	-
EGAD00001004252	WGS and RNA-Seq data from a GBM patient PT-LS4891	Illumina HiSeq 2000	-
EGAD00001004253	WGS and RNA-Seq data from a GBM patient PT-MB9777	Illumina HiSeq 2000 Illumina HiSeq 2500	3
EGAD00001004254	WGS and RNA-Seq data from a GBM patient PT-MD9088	Illumina HiSeq 2500	1
EGAD00001004255	WGS and RNA-Seq data from a GBM patient PT-PD6881	Illumina HiSeq 2000 Illumina HiSeq 2500	1
EGAD00001004256	WGS and RNA-Seq data from a GBM patient PT-RD1291	Illumina HiSeq 2000 Illumina HiSeq 2500	-
EGAD00001004257	WGS and RNA-Seq data from a GBM patient PT-RL5404	Illumina HiSeq 2000	1
EGAD00001004258	WGS and RNA-Seq data from a GBM patient PT-RL7940	Illumina HiSeq 2000	-
EGAD00001004259	WGS and RNA-Seq data from a GBM patient PT-RW9277	Illumina HiSeq 2000 Illumina HiSeq 2500	1
EGAD00001004260	WGS and RNA-Seq data from a GBM patient PT-SK0976	Illumina HiSeq 2000 Illumina HiSeq 2500	1
EGAD00001004261	WGS and RNA-Seq data from a GBM patient PT-SO0258	Illumina HiSeq 2000	1
EGAD00001004262	WGS and RNA-Seq data from a GBM patient PT-TM5196	Illumina HiSeq 2500	1
EGAD00001004263	WGS and RNA-Seq data from a GBM patient PT-VO7089	Illumina HiSeq 2000 Illumina HiSeq 2500	-
EGAD00001004264	WGS data from a GBM patient PT-WP9124	Illumina HiSeq 2500	1
EGAD00001008516	WGS and RNA-Seq data from a GBM patient PT-BM8772	Illumina HiSeq 2500	1
EGAD00001008517	WGS and RNA-Seq data from a GBM patient PT-CM3220	Illumina HiSeq 2000 Illumina HiSeq 2500	2
EGAD00001008518	WGS and RNA-Seq data from a GBM patient PT-DM9089	Illumina HiSeq 2000 Illumina HiSeq 2500	2
EGAD00001008519	WGS and RNA-Seq data from a GBM patient PT-GE7528	Illumina HiSeq 2000	1
EGAD00001008520	WGS and RNA-Seq data from a GBM patient PT-GI2070	Illumina HiSeq 2000	1
EGAD00001008521	WGS and RNA-Seq data from a GBM patient PT-JR9883	Illumina HiSeq 2000	1
EGAD00001008522	WGS and RNA-Seq data from a GBM patient PT-LC6372	Illumina HiSeq 2500	1
EGAD00001008523	WGS and RNA-Seq data from a GBM patient PT-ML9537	Illumina HiSeq 2500	1
EGAD00001008524	WGS data from a GBM patient PT-MS8478		-
EGAD00001008525	WGS and RNA-Seq data from a GBM patient PT-PR5617	Illumina HiSeq 2000 Illumina HiSeq 2500	2
EGAD00001008526	WGS and RNA-Seq data from a GBM patient PT-PV2594	Illumina HiSeq 2000 Illumina HiSeq 2500	5
EGAD00001008527	WGS and RNA-Seq data from a GBM patient PT-RV2286	Illumina HiSeq 2500	1
EGAD00001008528	WGS data from a GBM patient PT-SB3465		-
EGAD00001008529	WGS and RNA-Seq data from a GBM patient PT-SJ5453	Illumina HiSeq 2000 Illumina HiSeq 2500	3
EGAD00001008530	WGS and RNA-Seq data from a GBM patient PT-SS3647	Illumina HiSeq 2000 Illumina HiSeq 2500	3
EGAD00001008531	WGS and RNA-Seq data from a GBM patient PT-WR7927	Illumina HiSeq 2500	1
EGAD00001008532	WGS and RNA-Seq data from a GBM patient PT-WT4796	Illumina HiSeq 2000	1

Publications	Citations
Comprehensive genomic profiling of glioblastoma tumors, BTICs, and xenografts reveals stability and adaptation to growth environments. Shen Y, Grisdale CJ, Islam SA, Bose P, Lever J, Zhao EY, Grinshtein N, Ma Y, Mungall AJ, Moore RA, Lun X, Senger DL, Robbins SM, Wang AY, MacIsaac JL, Kobor MS, Luchman HA, Weiss S, Chan JA, Blough MD, Kaplan DR, Cairncross JG, Marra MA, Jones SJM. Proc Natl Acad Sci U S A 116: 2019 19098-19108	26
SLUG Directs the Precursor State of Human Brain Tumor Stem Cells. Chesnelong C, Hao X, Cseh O, Wang AY, Luchman HA, Weiss S. Cancers (Basel) 11: 2019 E1635	8
Glioma-derived IL-33 orchestrates an inflammatory brain tumor microenvironment that accelerates glioma progression. De Boeck A, Ahn BY, D'Mello C, Lun X, Menon SV, Alshehri MM, Szulzewsky F, Shen Y, Khan L, Dang NH, Reichardt E, Goring KA, King J, Grisdale CJ, Grinshtein N, Hambardzumyan D, Reilly KM, Blough MD, Cairncross JG, Yong VW, Marra MA, Jones SJM, Kaplan DR, McCoy KD, Holland EC, Bose P, Chan JA, Robbins SM, Senger DL. Nat Commun 11: 2020 4997	83
Spatiotemporal modeling reveals high-resolution invasion states in glioblastoma. Manoharan VT, Abdelkareem A, Gill G, Brown S, Gillmor A, Hall C, Seo H, Narta K, Grewal S, Dang NH, Ahn BY, Osz K, Lun X, Mah L, Zemp F, Mahoney D, Senger DL, Chan JA, Morrissy AS. Genome Biol 25: 2024 264	0