Somatic mutation and clonal evolution in premalignant lung disease WGS
|Study ID||Alternative Stable ID||Type|
Study Datasets 1 dataset.
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Cancer is a genetic disease caused by an accumulations of mutations, however many of these mutations have been identified in pathologically normal tissue. We aim to use laser-capture microscopy (LCM) to sample individual clones from the lung tissue of individuals with a variety of lung diseases (COPD, UIP, IPF, Emphysema, pulmonary hypertension). This will allow us to identify whether cancer-associated mutations appear in this normal tissue, assess the mutational burden present, and identify ... (Show More)
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