Genomic analysis Nasopharyngeal cancer through whole exome sequencing and whole genomic sequencing.

Study ID Alternative Stable ID Type
EGAS00001002788 Other

Study Description

Nasopharyngeal carcinoma (NPC) is a squamous-cell carcinoma and has remarkable ethnic and geographic distribution, with a high prevalence in southern China, southeast Asia, northern Africa and Alaska. Although there are previous studies implicated NF-κB pathway play an important role in NPC. Newer research also found several important cellular processes and pathways in NPC, including chromatin modification, ERBB-PI3K signaling and autophagy machinery. Put these studies together, although, NPC is still poorly understood at the genetic level. Here we determined the mutational landscape of 553 cases with NPC using whole-genomic and whole-exome sequencing. These approaches revealed a distinct mutational signature and significantly mutated genes.

Study Datasets 1 dataset.

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Dataset ID Description Technology Samples
This dataset include NPC blood tumor pair sequencing bam file, include 21 pairs, 42 bam files
Illumina HiSeq 2000 42

Who archives the data?

There are no publications available