Study

Sensitive and Frequent Identification of High Avidity Neo-epitope Specific CD8 + T-cells in Immunotherapy-naïve Ovarian Cancer

Study ID Alternative Stable ID Type
EGAS00001002803 Other

Study Description

Immunotherapy directed against private tumor neo-antigens derived from non-synonymous somatic mutations is a promising strategy of personalized cancer immunotherapy. However, feasibility in low mutational load tumor types remains unknown. Comprehensive and deep analysis of circulating and tumor-infiltrating lymphocytes (TILs) for neo-epitope specific CD8 + T cells allowed prompt identification of oligoclonal and polyfunctional such cells from most immunotherapy-naïve patients with advanced epithelial ovarian cancer studied. Neo-epitope recognition was discordant between circulating T cells and TILs, and was more likely to be found among TILs, which displayed higher functionalavidity and unique TCRs with higher predicted affinity than their blood counterparts. Our results imply that identification of neo-epitope specific CD8 + T cells is achievable even in tumors with relatively low number of somatic mutations, and neo-epitope validation in TILs extends opportunities for mutanome-based personalized immunotherapies to such tumors.

Study Datasets 3 datasets.

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Dataset ID Description Technology Samples
EGAD00001003916
Cancer exomes consisting of FASTQ paired-end reads from ovary samples
Illumina HiSeq 2500 19
EGAD00001003917
Germline exomes consisting of FASTQ paired-end reads from blood samples
Illumina HiSeq 2500 19
EGAD00001003918
Cancer RNA-seq consisting of FASTQ paired-end reads from ovary samples
Illumina HiSeq 2500 16

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