Exome and RNA sequencing data from 32 ocular and extraocular sebaceous carcinomas
|Study ID||Alternative Stable ID||Type|
Study Datasets 1 dataset.
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Sebaceous carcinomas (SeC) are cutaneous malignancies that, in rare cases, metastasize and prove fatal. Here we report whole exome sequencing on 32 SeC, revealing distinct mutational classes that explain both cancer ontogeny and clinical course. A UV-damage signature predominated 10/32 samples, while 9 were instead defined by microsatellite instability (MSI) mutations. UV-damage SeC exhibited poorly differentiated, infiltrative histopathologycompared to MSI signature SeC (p = 0.003), features ... (Show More)
|Illumina HiSeq 2500||79|