Whole genome analysis of mutation hotspots in gastric cancer
Tissue-specific driver mutations in non-coding genomic regions remain undefined for most cancer types. In this study, we unbiasedly analysed 212 gastric cancer whole genomes to identify recurrently mutated non-coding regions in gastric cancer. Applying comprehensive statistical approa- ches to accurately model background mutational processes, we observe significant enrich- ment of non-coding indels (insertions/deletions) in three gastric lineage-specific genes. We further identify 34 mutation hotspots, of which 11 overlap CTCF binding sites (CBSs).
- Type: Other
- Archiver: European Genome-Phenome Archive (EGA)
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|HiSeq X Ten Illumina HiSeq 2000 Illumina HiSeq 2500
Mutation hotspots at CTCF binding sites coupled to chromosomal instability in gastrointestinal cancers.
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