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Whole genome analysis of mutation hotspots in gastric cancer

Tissue-specific driver mutations in non-coding genomic regions remain undefined for most cancer types. In this study, we unbiasedly analysed 212 gastric cancer whole genomes to identify recurrently mutated non-coding regions in gastric cancer. Applying comprehensive statistical approa- ches to accurately model background mutational processes, we observe significant enrich- ment of non-coding indels (insertions/deletions) in three gastric lineage-specific genes. We further identify 34 mutation hotspots, of which 11 overlap CTCF binding sites (CBSs).

Click on a Dataset ID in the table below to learn more, and to find out who to contact about access to these data

Dataset ID Description Technology Samples
EGAD00001004279 HiSeq X Ten Illumina HiSeq 2000 Illumina HiSeq 2500 80
Publications Citations
Mutation hotspots at CTCF binding sites coupled to chromosomal instability in gastrointestinal cancers.
Nat Commun 9: 2018 1520
ERR-activated GPR35 promotes immune infiltration level of macrophages in gastric cancer tissues.
Cell Death Discov 8: 2022 444