Hypothalamic transcriptome in Prader-Willi syndrome - EGA European Genome-Phenome Archive

Study

Hypothalamic transcriptome in Prader-Willi syndrome

Study ID	Alternative Stable ID	Type
EGAS00001002901		Other

Study Description

Transcriptional analysis of brain tissue from people with molecularly defined causes of obesity may highlight novel disease mechanisms and therapeutic targets. Prader-Willi syndrome (PWS) is a genetic obesity syndrome characterised by severe hyperphagia. We performed RNA sequencing of the hypothalamus from 4 individuals with PWS and 4 age-matched controls.

Study Datasets 1 dataset.

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Dataset ID	Description	Technology	Samples
EGAD00001004034	RNA-seq data (bam files) from the hypothalamus of 4 individuals with Prader-Willi syndrome and 4 age-matched control individuals. Detailed information about the study design, case-control matching and RNA-seq data processing is provided in the accompanying publication [Bochukova et al (2018) Cell Reports]. RNA-seq data (bam files) from the hypothalamus of 4 individuals with Prader-Willi syndrome and 4 age-matched control individuals. Detailed information about the study design, case-control matching and RNA-seq data processing is provided in the accompanying publication [Bochukova et al (2018) Cell Reports].	Illumina HiSeq 2000	8

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