SS18-SSX-mediated hijacking of BAF complexes drives synovial sarcoma
|Study ID||Alternative Stable ID||Type|
Study Datasets 1 dataset.
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Synovial sarcoma (SS) is defined by a recurrent t(x;18) chromosomal translocation, which produces the hallmark SS18-SSX oncogenic fusion. Incorporation of SS18-SSX into BAF complexes renders BAF complexes aberrant in two distinct manners: the addition of 78aa of SSX onto SS18, and concomitant loss of BAF47 assembly. However, the importance and functional contributions of each of these perturbations on BAF complex targeting and gene expression regulation remain unclear. Here we use an ... (Show More)
|Illumina HiSeq 2000,NextSeq 500||85|