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RNA-seq analysis of human skin

RNA sequencing analysis comparing epidermal subpopulations in normal and inflamed skin.

Type: Other
Archiver: European Genome-Phenome Archive (EGA)

2 Datasets 19 Publications

Click on a Dataset ID in the table below to learn more, and to find out who to contact about access to these data

Dataset ID	Description	Technology	Samples
EGAD00001004367	Single cell RNA-seq analysis of human skin.	Illumina NovaSeq 6000	12
EGAD00010001620	Single cell RNA-seq analysis of human skin.	single cell RNA-seq	12

Publications	Citations
Transcriptional Programming of Normal and Inflamed Human Epidermis at Single-Cell Resolution. Cheng JB, Sedgewick AJ, Finnegan AI, Harirchian P, Lee J, Kwon S, Fassett MS, Golovato J, Gray M, Ghadially R, Liao W, Perez White BE, Mauro TM, Mully T, Kim EA, Sbitany H, Neuhaus IM, Grekin RC, Yu SS, Gray JW, Purdom E, Paus R, Vaske CJ, Benz SC, Song JS, Cho RJ. Cell Rep 25: 2018 871-883	135
Single-Cell Transcriptomics Reveals Spatial and Temporal Turnover of Keratinocyte Differentiation Regulators. Finnegan A, Cho RJ, Luu A, Harirchian P, Lee J, Cheng JB, Song JS. Front Genet 10: 2019 775	33
SARS-CoV-2 entry factors are highly expressed in nasal epithelial cells together with innate immune genes. Sungnak W, Huang N, Bécavin C, Berg M, Queen R, Litvinukova M, Talavera-López C, Maatz H, Reichart D, Sampaziotis F, Worlock KB, Yoshida M, Barnes JL, HCA Lung Biological Network. Nat Med 26: 2020 681-687	1591
Contribution of GATA6 to homeostasis of the human upper pilosebaceous unit and acne pathogenesis. Oulès B, Philippeos C, Segal J, Tihy M, Vietri Rudan M, Cujba AM, Grange PA, Quist S, Natsuga K, Deschamps L, Dupin N, Donati G, Watt FM. Nat Commun 11: 2020 5067	28
Single cell transcriptional zonation of human psoriasis skin identifies an alternative immunoregulatory axis conducted by skin resident cells. Gao Y, Yao X, Zhai Y, Li L, Li H, Sun X, Yu P, Xue T, Li Y, Hu Y. Cell Death Dis 12: 2021 450	34
Glutamic acid promotes hair growth in mice. Jara CP, de Andrade Berti B, Mendes NF, Engel DF, Zanesco AM, Pereira de Souza GF, de Medeiros Bezerra R, de Toledo Bagatin J, Maria-Engler SS, Morari J, Velander WH, Velloso LA, Araújo EP. Sci Rep 11: 2021 15453	8
Oncostatin M can sensitize sensory neurons in inflammatory pruritus. Tseng PY, Hoon MA. Sci Transl Med 13: 2021 eabe3037	34
Embigin is a fibronectin receptor that affects sebaceous gland differentiation and metabolism. Sipilä K, Rognoni E, Jokinen J, Tewary M, Vietri Rudan M, Talvi S, Jokinen V, Dahlström KM, Liakath-Ali K, Mobasseri A, Du-Harpur X, Käpylä J, Nutt SL, Salminen TA, Heino J, Watt FM. Dev Cell 57: 2022 1453-1465.e7	8
Differentiation-related epigenomic changes define clinically distinct keratinocyte cancer subclasses. Solé-Boldo L, Raddatz G, Gutekunst J, Gilliam O, Bormann F, Liberio MS, Hasche D, Antonopoulos W, Mallm JP, Lonsdorf AS, Rodríguez-Paredes M, Lyko F. Mol Syst Biol 18: 2022 e11073	4
Revisiting the significance of keratin expression in complex epithelia. Cohen E, Johnson C, Redmond CJ, Nair RR, Coulombe PA. J Cell Sci 135: 2022 jcs260594	6
Single cell RNA-seq of human cornea organoids identifies cell fates of a developing immature cornea. Maiti G, Monteiro de Barros MR, Hu N, Dolgalev I, Roshan M, Foster JW, Tsirigos A, Wahlin KJ, Chakravarti S. PNAS Nexus 1: 2022 pgac246	8
A prediction model identifying glycolysis signature as therapeutic target for psoriasis. Shou Y, Zhu R, Tang Z, Man XY. Front Immunol 14: 2023 1188745	3
Decoding the Human Epidermal Complexity at Single-Cell Resolution. Polito MP, Marini G, Palamenghi M, Enzo E. Int J Mol Sci 24: 2023 8544	6
Significance of stress keratin expression in normal and diseased epithelia. Cohen E, Johnson CN, Wasikowski R, Billi AC, Tsoi LC, Kahlenberg JM, Gudjonsson JE, Coulombe PA. iScience 27: 2024 108805	5
Skin single-cell transcriptomics reveals a core of sebaceous gland-relevant genes shared by mice and humans. Thalheim T, Schneider MR. BMC Genomics 25: 2024 137	2
Short cell cycle duration is a phenotype of human epidermal stem cells. Xiao T, Eze UC, Charruyer-Reinwald A, Weisenberger T, Khalifa A, Abegaze B, Schwab GK, Elsabagh RH, Parenteau TR, Kochanowski K, Piper M, Xia Y, Cheng JB, Cho RJ, Ghadially R. Stem Cell Res Ther 15: 2024 76	0
Distinct melanocyte subpopulations defined by stochastic expression of proliferation or maturation programs enable a rapid and sustainable pigmentation response. Aggarwal A, Nasreen A, Sharma B, Sahoo S, Aswin K, Faruq M, Pandey R, Jolly MK, Singh A, Gokhale RS, Natarajan VT. PLoS Biol 22: 2024 e3002776	0
The role of cell-cell and cell-matrix junctional complexes in sebaceous gland homeostasis and differentiation. Yaba A, Thalheim T, Schneider MR. Cell Commun Signal 22: 2024 445	0
Visualizing scRNA-Seq data at population scale with GloScope. Wang H, Torous W, Gong B, Purdom E. Genome Biol 25: 2024 259	1