Integrated Genomic, Epigenetic, and Expression Analyses of Ovarian Cancer Cell Lines

Study ID Alternative Stable ID Type
EGAS00001002998 Other

Study Description

Epithelial ovarian carcinoma of all subtypes has one of the worst outcomes of any human cancer. To improve our understanding of underlying biology and therapeutic possibilities in this disease, we performed whole genome sequencing, methylation, and expression analyses of a comprehensive set of 47 ovarian cancer cell lines representing different histologic tumor subtypes. Given the challenges of genomic analyses in tumors without matched normal samples, we developed novel approaches for detection of somatic alterations and used these to identify sequence, copy number, and rearrangement changes and integrated these with genome-wide epigenetic and expression alterations. Ovarian cancer cell lines had molecular changes in genes involved in cell cycle, PI3K, RAS, BRCA, chromatin regulating, and p53 pathways, and displayed global mutation and methylation changes similar to primary ovarian carcinoma. We identified alterations not previously implicated in ovarian cancer including amplification or overexpression of ASXL1 and H3F3B, deletion or underexpression of CDC73 and members of the TGF ... (Show More)

Study Datasets 1 dataset.

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Dataset ID Description Technology Samples
In this dataset there are 55 whole genome sequencing samples of epithelial ovarian carcinoma (bam files).
Illumina HiSeq 2500 55

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