Study

Celiac disease-specific intestinal T cells analyzed with HLA-class II tetramers, RNA-seq and mass cytometry have a narrow, autoimmune-associated phenotype

Study ID Alternative Stable ID Type
EGAS00001003017 Other

Study Description

Celiac disease (CD) is an HLA-DQ2/8-associated autoimmune enteropathy driven by activation of gluten-specific CD4+ T lymphocytes upon gluten consumption. Much less is known about the phenotype and function of these cells or their correlation, if any, to disease-relevant cells in other autoimmune disorders. Here we use mass cytometry and RNA seq to show that gluten-specific blood and gut T cells occupy a small and phenotypically distinct T-cell subset.

Study Datasets 1 dataset.

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Dataset ID Description Technology Samples
EGAD00001004146
Total RNA-seq of intestinal gluten tetramer+ and tetramer- CD4+ T-cells from celiac disease patients, as well as intestinal CD4+ T-cells from healthy control individuals (paired-end fastq files).
14

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