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Exome sequencing of advanced hepatocellular carcinoma

The aim of our project is to decipher the genomic of advanced hepatocellular carcinoma using whole exome sequencing. To this purpose, we aim to compare genetic landscape of advanced hepatocellular carcinoma with early tumor in order to understand the mechanisms of tumor progression. This work will also help to identify new therapeutic targets potentially useful to treat patients at advanced stage. This study contain whole exome sequencing aligned reads for 41 tumor with matched normal samples

Click on a Dataset ID in the table below to learn more, and to find out who to contact about access to these data

Dataset ID Description Technology Samples
EGAD00001004555 Illumina HiSeq 2000 Illumina HiSeq 4000 39
Publications Citations
Clinical Impact of Genomic Diversity From Early to Advanced Hepatocellular Carcinoma.
Hepatology 71: 2020 164-182
54
Hepatitis B virus integrations promote local and distant oncogenic driver alterations in hepatocellular carcinoma.
Gut 71: 2022 616-626
58