DNA methylomes of monozygotic twins clinically discordant for multiple sclerosis

Study ID Alternative Stable ID Type
EGAS00001003147 Other

Study Description

Multiple sclerosis (MS) is an inflammatory demyelinating disease of the central nervous system. Although genetic susceptibility is important, a modest concordance rate for MS in monozygotic (MZ) twins suggests that interaction with other risk factors is required to develop clinical symptoms. In this study, we examined whether DNA methylation differences contribute to the discordant clinical manifestation of MS in MZ twins, and studied the impact of MS treatments on the DNA methylome. Genome-wide DNA methylation profiles of peripheral blood mononuclear cells (PBMCs) of 45 MZ twins clinically discordant for MS were generated using the Illumina HumanMethylationEPIC array. Repetitive element methylation and selected differentially methylated positions (DMPs) were validated using targeted deep bisulfite sequencing (TDBS). In addition, we performed whole genome bisulfite sequencing (WGBS) to profile CD4+ memory T-cells of a subset of four MS discordant MZ twins. Our results show that interferon treatment causes robust DNA methylation changes and several epigenetic biomarkers for ... (Show More)

Study Datasets 1 dataset.

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Dataset ID Description Technology Samples
Genome-wide DNA methylation profiles of MZ twins clinically discordant for MS generated using Illumina’s Infinium MethylationEPIC BeadChip assay (EPIC array)
Illumina Infinium MethylationEPIC BeadChip assay 90

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