Study

The molecular landscape of glioma in patients with Neurofibromatosis 1.

Study ID Alternative Stable ID Type
EGAS00001003186 Other

Study Description

Neurofibromatosis type 1 (NF1) is a common tumor predisposition syndrome in which glioma is one of the most prominent tumor type. Gliomagenesis in NF1 results in heterogeneous spectrum of tumors, from low grade to high grade glioma, occurring during the entire patient lifespan. In this study, we present the molecular landscape of low- and high-grade glioma in children and adults affected by NF1 (NF1-glioma). 59 tumor samples from 56 NF1-glioma patients with 43 matched normal were profiled with Whole Exome Sequencing, DNA Methylation array (31 tumors) and RNA sequencing (29 tumors).

Study Datasets 4 datasets.

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Dataset ID Description Technology Samples
EGAD00001004374
The dataset includes 43 matched normal samples from 43 NF1-glioma patients profiled by Whole Exome Sequencing.
Illumina HiSeq 2500 43
EGAD00001004375
The dataset includes 59 tumor samples from 56 NF1-glioma patients profiled by Whole Exome Sequencing.
Illumina HiSeq 2500 59
EGAD00001004376
The dataset includes 29 tumor samples from NF1-glioma patients profiled by RNA sequencing.
Illumina HiSeq 2500 29
EGAD00010001610
DNA methylation of NF1-glioma
Illumina 850K Epic Array 31

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