Study

ERBB2/HER2 transmembrane and juxtamembrane domain mutations in cancer

Study ID Alternative Stable ID Type
EGAS00001003213 Other

Study Description

In this study, we identified several recurrent activating HER2 somatic mutations in transmembrane and juxtamembrane domain in multiple cancers and demonstrate that patients carryingthese mutations are candidates for anti-HER2 therapy. We have also identified a germline mutation in HER2 transmembrane domain.

Study Datasets 1 dataset.

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Dataset ID Description Technology Samples
EGAD00001004351
ERBB2/HER2 transmembrane and juxtamembrane domain mutations in cancer. Exome sequencing of tumor and matched blood and 2 blood samples from relatives.
Illumina HiSeq 2500 4

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