Fecal Microbiota Transplantation for refractory immune checkpoint inhibitor-associated colitis
We report the first case series of ICI associated colitis successfully treated with fecal microbiota transplantation (FMT), with reconstitution of the gut microbiome and a relative increase in the proportion of regulatory T cells (Tregs) within the colonic mucosa. These preliminary data provide evidence that modulation of the gut microbiome may abrogate ICI-associated colitis.
- Type: Other
- Archiver: EGA European Genome-Phenome Archive
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Fecal microbiota transplantation for refractory immune checkpoint inhibitor-associated colitis.
Nat Med 24: 2018 1804-1808