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Fecal Microbiota Transplantation for refractory immune checkpoint inhibitor-associated colitis

We report the first case series of ICI associated colitis successfully treated with fecal microbiota transplantation (FMT), with reconstitution of the gut microbiome and a relative increase in the proportion of regulatory T cells (Tregs) within the colonic mucosa. These preliminary data provide evidence that modulation of the gut microbiome may abrogate ICI-associated colitis.

Click on a Dataset ID in the table below to learn more, and to find out who to contact about access to these data

Dataset ID Description Technology Samples
EGAD00001004371 Illumina MiSeq 11
Publications Citations
Fecal microbiota transplantation for refractory immune checkpoint inhibitor-associated colitis.
Nat Med 24: 2018 1804-1808