Epigenetics/genetics of the patient-derived xenografts of pediatric T-cell leukemia

Study ID Alternative Stable ID Type
EGAS00001003248 Other

Study Description

We compared 12 pediatric T cell acute lymphoblastic leukemias collected at initial diagnosis and relapse with their corresponding PDX models. The analysis was performed on genomic level (whole genome sequencing (WGS), whole exome sequencing (WES), multiplex ligation probe amplification (MLPA), targeted sequencing) and the epigenetic level (DNA methylation, Assay for Transposase-Accessible Chromatin sequencing (ATAC-seq)). In sum, this study underlines the remarkable genomic stability, and for the first time documents the preservation of the epigenomic landscape in T-ALL-derived PDX models.

Study Datasets 1 dataset.

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Dataset ID Description Technology Samples
Each dataset cosist of WES data from 5 samples (1 patient): original leukemia initial diagnosis T-ALL, original leukemia relapse T-ALL, PDX derived of initial diagnosis T-ALL, PDX derived of relapse T-ALL, remission (normal control)
Illumina HiSeq 2000,Illumina HiSeq 2500,NextSeq 500 164

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