A GWAS meta-analysis on severe acne on a European population of 26,722 individuals

Acne vulgaris is a highly heritable common, chronic inflammatory disease of the skin. We performed a genome-wide association study of 3,823 cases and 16,144 controls followed by meta-analysis with summary statistics from a previous study, with a total sample size of 26,722. We identified 20 independent association signals at 15 risk loci, 12 of which have not been previously implicated in the disease.

Type: Other
Archiver: European Genome-Phenome Archive (EGA)

1 Dataset 1 Publication

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Dataset ID	Description	Technology	Samples
EGAD00001004419	Summary statistics of a GWAS meta-analysis for severe acne. A total of 7,441,713 genotyped and imputed variants were used for 5,602 European severe acne cases and 21,120 matched population controls.		1

Publications	Citations
Genome-wide meta-analysis implicates mediators of hair follicle development and morphogenesis in risk for severe acne. Petridis C, Navarini AA, Dand N, Saklatvala J, Baudry D, Duckworth M, Allen MH, Curtis CJ, Lee SH, Burden AD, Layton A, Bataille V, Pink AE, Acne Genetic Study Group, Carlavan I, Voegel JJ, Spector TD, Trembath RC, McGrath JA, Smith CH, Barker JN, Simpson MA. Nat Commun 9: 2018 5075	12

Publications

Citations

Genome-wide meta-analysis implicates mediators of hair follicle development and morphogenesis in risk for severe acne.
Petridis C, Navarini AA, Dand N, Saklatvala J, Baudry D, Duckworth M, Allen MH, Curtis CJ, Lee SH, Burden AD, Layton A, Bataille V, Pink AE, Acne Genetic Study Group, Carlavan I, Voegel JJ, Spector TD, Trembath RC, McGrath JA, Smith CH, Barker JN, Simpson MA. Nat Commun 9: 2018 5075