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Personalized RNA mutanome vaccines mobilize poly-specific therapeutic immunity against cancer

The goal of the sequencing study was to determine the neoantigen profile of melanoma patients. We performed whole exome sequening of the tumor and respective patien matched PBMC samples (2x50nt) and RNA-sqeuencing of the tumor samples. The was analyzed for somatic point mutaions, using the RNA-Seq data to determine mutation expression. This study contains the exome seq data.

Click on a Dataset ID in the table below to learn more, and to find out who to contact about access to these data

Dataset ID Description Technology Samples
EGAD00001004455 Illumina HiSeq 2500 72
Publications Citations
Accurate detection of tumor-specific gene fusions reveals strongly immunogenic personal neo-antigens.
Nat Biotechnol 40: 2022 1276-1284