Study

Microsatellite unstable colorectal cancers

Study ID Alternative Stable ID Type
EGAS00001003366 Other

Study Description

Immune escape has been recognised as one of the hallmarks of cancer. Overcoming this immunomodulatory process by tumour cells has become a major therapeutic target. Here we utilize organoid technology to study immune-cancer interactions and assess immunomodulation by colorectal cancer (CRC). Transcriptional profiling and flow cytometry revealed that organoids maintain differential expression of immunomodulatory molecules present in primary tumours. Finally, we established a method to model antigen-specific epithelial cell killing and cancer immunomodulation in vitro using CRC organoids co-cultured with cytotoxic T cells. Our method may serve as a first step to rebuilding the tumor microenvironment in vitro.

Study Datasets 1 dataset.

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Dataset ID Description Technology Samples
EGAD00001004500
Mapped data for 10 Colon MSI cancer samples
Illumina HiSeq 2500 10

Who archives the data?

There are no publications available