Study
HSC population dynamics CB001 samples
| Study ID | Alternative Stable ID | Type |
|---|---|---|
| EGAS00001003397 | Cancer Genomics |
Study Description
My research project aims to use the clonal dynamics of spontaneously occurring somatic mutations to answer fundamental questions about human haematopoietic stem cell (HSC) biology.
The four major questions I will address are:
1. How do age and aging affect normal human HSC dynamics in vivo?
2. How do in vivo perturbations, particularly chemotherapy and increased levels of reactive oxygen species, affect HSC population dynamics?
3. Is response to in vitro perturbation heritable and/or correlated with other features such as age of individual and contribution of the lineage to peripheral blood?
4. How are HSC dynamics altered in people with early driver mutations (clonal haematopoiesis)?
Study Datasets 1 dataset.
Click on a Dataset ID in the table below to learn more, and to find out who to contact about access to these data
| Dataset ID | Description | Technology | Samples |
|---|---|---|---|
| EGAD00001006595 |
This dataset contains 160 single-cell derived blood colonies from two neonates and 6 adults. It also contains 18 samples that were used as matched normals to call mutations in NanoSeq data (dataset EGAD00001006459).
|
HiSeq X Ten,Illumina NovaSeq 6000 | 176 |
Who archives the data?
