Pharmacogenomic analysis of patient-derived tumor cells in gynecologic cancers

Study ID Alternative Stable ID Type
EGAS00001003556 Other

Study Description

Gynecologic malignancy is one of the leading causes of mortality in female adults worldwide. Comprehensive genomic analysis has revealed a list of molecular aberrations that are essential to tumorigenesis, progression, and metastasis of gynecologic tumors. However, targeting such alterations has frequently led to treatment failures due to underlying genomic complexity and activation of various tumor cell survival pathway molecules. A compilation of molecular characterization of tumors with pharmacological drug response is the next step towards clinical application of patient-tailored treatment regimens. Toward this goal, we have established a library of 139 gynecologic tumors including cervical, endometrial, and epithelial ovarian cancers (EOCs) and uterine sarcomas that were genomically and/or pharmacologically annotated and explored dynamic pharmacogenomic associations against 37 molecularly targeted drugs. We discovered lineage-specific drug sensitivities based on subcategorization of gynecologic tumors and identified TP53 mutation as a molecular determinant that elicit ... (Show More)

Study Datasets 1 dataset.

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Dataset ID Description Technology Samples
Total of 180 gynecologic tumor specimens were subjected for targeted-exome and/or whole-transcriptome sequencing.
Illumina HiSeq 2500 180

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