Genetic Alterations in Benign Breast Biopsies of Subsequent Breast Cancer Patients
Fibrocystic changes are associated with an increased risk of breast cancer (approximately 1.5-2 times that of the general population). Although the relative risk seems low, because of the high frequency of such changes, the absolute risk is significant. Genetic alterations have been found in fibrocystic changes with or without epithelial changes, suggesting that critical oncogenic events are occurring at an early stage. We investigated a unique collective of 17 breast cancer patients who, prior to the diagnosis of invasive breast cancer, underwent open surgical biopsy showing fibrocystic changes of the breast. Massive parallel sequencing targeting genes frequently mutated in breast cancer was performed on the fibrocystic breast tissue as well as the ensuing cancer tissue.
- Type: Other
- Archiver: EGA European Genome-Phenome Archive
Click on a Dataset ID in the table below to learn more, and to find out who to contact about access to these data
|EGAD00001004874||Ion Torrent S5 XL||51|
|EGAD00001006356||Illumina HiSeq 2500 Illumina NovaSeq 6000 Ion Torrent S5 XL||288|
Genetic Alterations in Benign Breast Biopsies of Subsequent Breast Cancer Patients.
Front Med (Lausanne) 6: 2019 166