Multi-Region WES of Metastatic Colorectal Cancer

1 Dataset 2 Publications

Click on a Dataset ID in the table below to learn more, and to find out who to contact about access to these data

Dataset ID	Description	Technology	Samples
EGAD00001004896	In order to reconstruct the evolutionary history of metastatic colorectal cancer, we performed whole-exome sequencing of 12 metastatic colorectal cancer patients for whom the primary tumor and matched distant metastases to the brain (n=10) and liver (n=2). For 8 of the 12 patients, multiple regions (n=3-7) of the primary tumor and distant metastases were sequenced.	Illumina HiSeq 2000 Illumina HiSeq 2500	163

Publications	Citations
Quantitative evidence for early metastatic seeding in colorectal cancer. Hu Z, Ding J, Ma Z, Sun R, Seoane JA, Scott Shaffer J, Suarez CJ, Berghoff AS, Cremolini C, Falcone A, Loupakis F, Birner P, Preusser M, Lenz HJ, Curtis C. Nat Genet 51: 2019 1113-1122	220
Multi-cancer analysis of clonality and the timing of systemic spread in paired primary tumors and metastases. Hu Z, Li Z, Ma Z, Curtis C. Nat Genet 52: 2020 701-708	142