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Breast Cancer - immune clusters - RNA-seq

In this study we use expression data from breast cancer tumors to define immune clusters in breast cancer. Immune clusters have gradual levels of immune infiltration. In the intermediate immune infiltration cluster, we found a worse prognosis which is independent of known clinicopathological features. We also found the immune clusters associated with treatment response. Further using gene expression data and deconvolution algorithms to dissect the immune contexture of the clusters.

Click on a Dataset ID in the table below to learn more, and to find out who to contact about access to these data

Dataset ID Description Technology Samples
EGAD00001004985 NextSeq 500 97
Publications Citations
An independent poor-prognosis subtype of breast cancer defined by a distinct tumor immune microenvironment.
Nat Commun 10: 2019 5499
Sample Preparation Approach Influences PAM50 Risk of Recurrence Score in Early Breast Cancer.
Cancers (Basel) 13: 2021 6118