Study

GWAS Results from Danjou et al, Nature Genetics 2015

Study ID Alternative Stable ID Type
EGAS00001003645 Other

Study Description

We report genome-wide association study results for the levels of A1, A2 and fetal hemoglobins, analyzed for the first time concurrently. Integrating high-density array genotyping and whole-genome sequencing in a large general population cohort from Sardinia, we detected 23 associations at 10 loci. Five signals are due to variants at previously undetected loci: MPHOSPH9, PLTP-PCIF1, ZFPM1 (FOG1), NFIX and CCND3. Among the signals at known loci, ten are new lead variants and four are new independent signals. Half of all variants also showed pleiotropic associations with different hemoglobins, which further corroborated some of the detected associations and identified features of coordinated hemoglobin species production.

Study Datasets 1 dataset.

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Dataset ID Description Technology Samples
EGAD00010001722
GWAS results in epacts format for Danjou et al, Nature Genetics 2015
Illumina arrays 6305

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