Exploring the landscape of somatic mutations in normal tissue POL TGS
|Study ID||Alternative Stable ID||Type|
Study Datasets 1 dataset.
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Mutation accumulation over time in normal somatic cells contributes to cancer development and is proposed as a cause of ageing. DNA polymerases POLE and POLD1 replicate DNA with high fidelity during normal cell divisions. However, in some cancers defective proofreading due to acquired mutations in the exonuclease domains of POLE or POLD1 causes markedly elevated somatic mutation burdens with distinctive mutational signatures. POLE and POLD1 exonuclease domain mutations also cause familial ... (Show More)
|Illumina HiSeq 4000,Illumina NovaSeq 6000||211|